Synthesis of Pyridyl-dihydrobenzooxaphosphole Ligands and Their Application in Asymmetric Hydrogenation of Unfunctionalized Alkenes
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- 作者：Bo Qu ; Lalith P. Samankumara ; Jolaine Savoie ; Daniel R. Fandrick ; Nizar Haddad ; Xudong Wei ; Shengli Ma ; Heewon Lee ; Sonia Rodriguez ; Carl A. Busacca ; Nathan K. Yee ; Jinhua J. Song ; Chris H. Senanayake
- 刊名：Journal of Organic Chemistry
- 出版年：2014
- 出版时间：February 7, 2014
- 年：2014
- 卷：79
- 期：3
- 页码：993-1000
- 全文大小：380K
- ISSN：1520-6904
文摘
Synthesis of the electron-rich 2-substituted-6-(phenylsulfonyl)pyridines is presented. A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed and synthesized by a diastereoselective SNAr substitution of the corresponding sulfonyl pyridines. The ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of unfunctionalized alkenes with good enantioselectivities.