Organocatalytic oxa/aza-Michael鈥揗ichael Cascade Strategy for the Construction of Spiro [Chroman/Tetrahydroquinoline-3,3鈥?oxindole] Scaffolds
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- 作者：Haibin Mao ; Aijun Lin ; Yang Tang ; Yan Shi ; Hongwen Hu ; Yixiang Cheng ; Chengjian Zhu
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：August 16, 2013
- 年：2013
- 卷：15
- 期：16
- 页码：4062-4065
- 全文大小：337K
- 年卷期：v.15,no.16(August 16, 2013)
- ISSN：1523-7052
文摘
A new useful and effective chiral amine-catalyzed oxa- and aza-Michael鈥揗ichael cascade methodology for the construction of enantiomerically enriched indolinones spiro-fused with chromans or tetrahydroquinolines is reported. By employing suitable organocatalysts depending on the different Michael donors (Ar-OH/Ar-NHR), the processes offered excellent stereocontrol (dr >20:1, >99% ee) under mild conditions.