Nickel-Catalyzed Site-Selective Alkylation of Unactivated C(sp3)–H Bonds

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• 作者：Xuesong Wu ; Yan Zhao ; Haibo Ge
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：February 5, 2014
• 年：2014
• 卷：136
• 期：5
• 页码：1789-1792
• 全文大小：323K
• ISSN：1520-5126

文摘

The direct alkylation of unactivated sp³ C鈥揌 bonds of aliphatic amides was achieved via nickel catalysis with the assist of a bidentate directing group. The reaction favors the C鈥揌 bonds of methyl groups over the methylene C鈥揌 bonds and tolerates various functional groups. Moreover, this reaction shows a predominant preference for sp³ C鈥揌 bonds of methyl groups via a five-membered ring intermediate over the sp² C鈥揌 bonds of arenes in the cyclometalation step.