Palladium-Catalyzed Chemoselective Decarboxylative Ortho Acylation of Benzoic Acids with 伪-Oxocarboxylic Acids

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• 作者：Jinmin Miao ; Haibo Ge
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 21, 2013
• 年：2013
• 卷：15
• 期：12
• 页码：2930-2933
• 全文大小：282K
• 年卷期：v.15,no.12(June 21, 2013)
• ISSN：1523-7052

文摘

Palladium-catalyzed chemoselective decarboxylative cross coupling of benzoic acids with 伪-oxocarboxylic acids was realized via an arene sp² C鈥揌 functionalization process. This work represents the first example of transition-metal-catalyzed cross-coupling reactions with two acids acting in different roles. The synthetic utility of this method was confirmed by the synthesis of pitofenone, an antispasmodic used in the combined drug Spasmalgon.