Di-tert-butyl Peroxide-Promoted 伪-Alkylation of 伪-Amino Carbonyl Compounds by Simple Alkanes

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• 作者：Haibo Peng ; Jin-Tao Yu ; Yan Jiang ; Haitao Yang ; Jiang Cheng
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：October 17, 2014
• 年：2014
• 卷：79
• 期：20
• 页码：9847-9853
• 全文大小：407K
• ISSN：1520-6904

文摘

A di-tert butyl peroxide (DTBP)-promoted 伪-alkylation of 伪-amino carbonyl compounds by simple alkanes is developed, proceeding through dual sp³ C鈥揌 bonds cleavage. The reaction was applicable for 伪-amino ketones and 伪-amino esters, providing a facile pathway for the 伪-functionalization of these substrates. The radical pathway is involved in this transformation.