The solid-phase synthesis of 纬-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing 纬-AApeptide building blocks in order to prepare 纬-AApeptide sequences. This method will maximize the potential of developing chemically diverse 纬-AApeptide libraries and thereby facilitate the biological applications of 纬-AApeptides in the future.