Solid-Phase Synthesis of 纬-AApeptides Using a Submonomeric Approach

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• 作者：Haifan Wu ; Mohamad Nassir Amin ; Youhong Niu ; Qiao Qiao ; Nassier Harfouch ; Abdelfattah Nimer ; Jianfeng Cai
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：July 6, 2012
• 年：2012
• 卷：14
• 期：13
• 页码：3446-3449
• 全文大小：239K
• 年卷期：v.14,no.13(July 6, 2012)
• ISSN：1523-7052

文摘

The solid-phase synthesis of 纬-AApeptides using a novel submonomeric approach that utilizes an allyl protection is reported. The strategy successfully circumvents the necessity of preparing 纬-AApeptide building blocks in order to prepare 纬-AApeptide sequences. This method will maximize the potential of developing chemically diverse 纬-AApeptide libraries and thereby facilitate the biological applications of 纬-AApeptides in the future.