Biocompatible, Antifouling, and Thermosensitive Core鈭扴hell Nanogels Synthesized by RAFT Aqueous Dispersion Polymerization

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• 作者：Wenqing Shen ; Yanli Chang ; Guangyao Liu ; Haifang Wang ; Aoneng Cao ; Zesheng An
• 刊名：Macromolecules
• 出版年：2011
• 出版时间：April 26, 2011
• 年：2011
• 卷：44
• 期：8
• 页码：2524-2530
• 全文大小：904K
• 年卷期：v.44,no.8(April 26, 2011)
• ISSN：1520-5835

文摘

Reversible addition鈭抐ragmentation chain transfer (RAFT) aqueous dispersion polymerization was used to synthesize a novel type of core鈭抯hell nanogel containing linear poly(ethylene glycol) (PEG) and/or nonlinear polymers with oligo(ethylene glycol) side chains. These nanogels with low polydispersities were synthesized efficiently with tunable sizes and thermosensitivities. The nanogels containing nonlinear polymers with oligo(ethylene glycol) side chains as the shell had enhanced stability during freeze鈭抰hawing process and in biologically relevant solutions including 1.5 M NaCl, 1% bovine serum albumin (BSA) and 100% fetal bovine serum (FBS) solutions. Aminolysis and hydrolysis of the chain transfer agents (CTAs) in the nanogels were studied and the nanogels exhibited enhanced stability in comparison with molecularly dissolved polymers. The chemical stability of the CTAs in the nanogels was well-correlated with the in vitro cell viability studies of the nanogels using lung cancer cells.