Triazole−Au(I) Complexes: A New Class of Catalysts with Improved Thermal Stability and Reactivity for Intermolecular Alkyne Hydroamination

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• 作者：Haifeng Duan ; Sujata Sengupta ; Jeffrey L. Petersen ; Novruz G. Akhmedov ; Xiaodong Shi
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：September 2, 2009
• 年：2009
• 卷：131
• 期：34
• 页码：12100-12102
• 全文大小：261K
• 年卷期：v.131,no.34(September 2, 2009)
• ISSN：1520-5126

文摘

A series of 1,2,3-triazole-bound cationic Au(I) catalysts have been synthesized, and their structures have been characterized by X-ray crystallography. Variable-temperature NMR studies revealed dynamic triazole−Au cation coordination in solution. Reaction profiles clearly indicated that these new catalysts possess much better thermal stability than literature-reported Au catalysts, including IPrAu·NTf₂. By application of these catalysts, challenging intermolecular hydroaminations were achieved with less-reactive internal alkynes and unprotected aliphatic amines, giving excellent yields with low catalyst loading.