Palladium-Catalyzed Tandem Fluorination and Cyclization of Enynes
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- 作者：Haihui Peng ; Guosheng Liu
- 刊名：Organic Letters
- 出版年：2011
- 出版时间：February 18, 2011
- 年：2011
- 卷：13
- 期：4
- 页码：772-775
- 全文大小：772K
- 年卷期：v.13,no.4(February 18, 2011)
- ISSN：1523-7052
文摘
A novel palladium-catalyzed tandem fluorination and cyclization of enynes has been developed. A favorable cis-fluoropalladation is proposed as a key step to construct a vinyl鈭扚 bond, and the final Csp3鈭扨d bond is reduced by alcohol. This transformation represents an efficient road to synthesize fluorinated lactams.