文摘
Significant synthetic challenges remain for the asymmetric synthesis of tertiary 伪-fluoro ketones, which are potentially useful molecules for the development of drugs, agrochemicals, and functional materials. Herein, we describe the development of a method for the catalytic enantioselective synthesis of tertiary 伪-fluoro ketones via the Tsuji鈥揟rost reaction of racemic acyclic 伪-fluorinated ketones. Enantioenriched acyclic 伪-cabonyl tertiary fluorides can be produced with the aid of a palladium/phosphinooxazoline catalyst.