pH-Sensitive Poly(histidine methacrylamide)

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• 作者：Huifeng Wang ; Haiyan Wu ; Chen-Jung Lee ; Xia Lei ; Jiang Zhe ; Fujian Xu ; Fang Cheng ; Gang Cheng
• 刊名：Langmuir
• 出版年：2016
• 出版时间：June 28, 2016
• 年：2016
• 卷：32
• 期：25
• 页码：6544-6550
• 全文大小：353K
• 年卷期：0
• ISSN：1520-5827

文摘

This research reports a synthetic amino acid based zwitterionic poly(histidine methacrylamide) (PHisMA), which possesses switchability among zwitterionic, anionic, and cationic states, pH-dependent antifouling properties, and chelation capability to multivalent metal ions. The PHisMA polymer brush surface shows good antifouling properties to resist protein adsorption and bacterial attachment in its zwitterionic state at pH 5. This study also demonstrates that the solution acidity significantly affects the mechanical properties of PHisMA hydrogels. PHisMA hydrogels show higher viscoelastic properties and lower swelling ratios in the zwitterionic state at pH 4 and pH 5, compared to higher or lower pH conditions. It was discovered that PHisMA can chelate multivalent metal ions, such as Ca²⁺, Mg²⁺, Cu²⁺, Ni²⁺ and Fe³⁺. This study provides us a better understanding of structure–property relationships of switchable zwitterionic polymers. PHisMA can potentially be adapted for a broad range of applications including wound care, water treatment, bioseparation, coating, drug and gene delivery carriers, etc.