Direct Arylation of Imidazo[1,2-a]pyridine at C-3 with Aryl Iodides, Bromides, and Triflates via Copper(I)-Catalyzed C鈥揌 Bond Functionalization
详细信息 查看全文
- 作者：Hua Cao ; Haiying Zhan ; Yuanguang Lin ; Xiulian Lin ; Zuodong Du ; Huanfeng Jiang
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：April 6, 2012
- 年：2012
- 卷：14
- 期：7
- 页码：1688-1691
- 全文大小：249K
- 年卷期：v.14,no.7(April 6, 2012)
- ISSN：1523-7052
文摘
A convenient method for the copper(I)-catalyzed arylation of substituted imidazo[1,2-a]pyridine has been developed. This method is applicable to a variety of aryl electrophiles, including bromides, iodides, and triflates. It represents the first general process for C-3 arylation of substituted imidazo[1,2-a]pyridine by Cu(I) catalysis to construct various functionalized imidazo[1,2-a]pyridine core 蟺-systems.