One-Pot Reductive Mono-N-alkylation of Aniline and Nitroarene Derivatives Using Aldehydes

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• 作者：Eunyoung Byun ; Bomi Hong ; Kathlia A. De Castro ; Minkyung Lim ; Hakjune Rhee
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：December 7, 2007
• 年：2007
• 卷：72
• 期：25
• 页码：9815 - 9817
• 全文大小：98K
• 年卷期：v.72,no.25(December 7, 2007)
• ISSN：1520-6904

文摘

One-pot reductive mono-N-alkylation of aniline and nitroarene derivatives using various aldehydes by Pd/C catalystin aqueous 2-propanol solvent with ammonium formate asin situ hydrogen donor is illustrated. The reaction proceededsmoothly and selectively with excellent yield at roomtemperature. Our protocol presents a facile, economical, andenvironmentally benign alternative for reductive amination.