Step-Economic Synthesis of (+)-Crocacin C: A Concise Crotylboronation/[3,3]-Sigmatropic Rearrangement Approach

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• 作者：Adele E. Pasqua ; Frank D. Ferrari ; Chris Hamman ; Yanzhou Liu ; James J. Crawford ; Rodolfo Marquez
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：August 17, 2012
• 年：2012
• 卷：77
• 期：16
• 页码：6989-6997
• 全文大小：408K
• 年卷期：v.77,no.16(August 17, 2012)
• ISSN：1520-6904

文摘

The step-economic total synthesis of (+)-crocacin C has been achieved in 20% yield from commercially available starting materials. This approach requires the isolation of only 8 intermediates and can provide a reliable supply of (+)-crocacin C for the development of new antifungal and crop protection agents.