Differentiating Between Cancer and Inflammation: A Metabolic-Based Method for Functional Computed Tomography Imaging

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• 作者：Menachem Motiei ; Tamar Dreifuss ; Oshra Betzer ; Hana Panet ; Aron Popovtzer ; Jordan Santana ; Galith Abourbeh ; Eyal Mishani ; Rachela Popovtzer
• 刊名：ACS Nano
• 出版年：2016
• 出版时间：March 22, 2016
• 年：2016
• 卷：10
• 期：3
• 页码：3469-3477
• 全文大小：513K
• ISSN：1936-086X

文摘

One of the main limitations of the highly used cancer imaging technique, PET-CT, is its inability to distinguish between cancerous lesions and post treatment inflammatory conditions. The reason for this lack of specificity is that [¹⁸F]FDG-PET is based on increased glucose metabolic activity, which characterizes both cancerous tissues and inflammatory cells. To overcome this limitation, we developed a nanoparticle-based approach, utilizing glucose-functionalized gold nanoparticles (GF-GNPs) as a metabolically targeted CT contrast agent. Our approach demonstrates specific tumor targeting and has successfully distinguished between cancer and inflammatory processes in a combined tumor-inflammation mouse model, due to dissimilarities in angiogenesis occurring under different pathologic conditions. This study provides a set of capabilities in cancer detection, staging and follow-up, and can be applicable to a wide range of cancers that exhibit high metabolic activity.