Experimental Determination of Metastable Zone Width, Induction Period, and Primary Nucleation Kinetics of Cytidine 5鈥?Monophosphate Disodium Salt in an Ethanol鈥揂queous Mixture

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• 作者：Jin Yu ; An Li ; Xiaochun Chen ; Yong Chen ; Jingjing Xie ; Jinglan Wu ; Hanjie Ying
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2013
• 出版时间：May 9, 2013
• 年：2013
• 卷：58
• 期：5
• 页码：1244-1248
• 全文大小：258K
• 年卷期：v.58,no.5(May 9, 2013)
• ISSN：1520-5134

文摘

A systematic investigation was carried out to determine the metastable zone width (MSZW) and induction period values of cytidine 5鈥?monophosphate disodium salt (5鈥?CMPNa₂) in an ethanol + water mixture solution. Experimental determination of the MSZW was performed using a laser method. The two factors solution temperature and agitation were evaluated in this study to measure the MSZW. It was observed that the MSZWs decreased when the agitation levels increased and were little affected by solution temperature. The induction period was combined with the classical theory of nucleation. The various critical nucleation parameters, such as the interfacial tension (纬), the radius of critical nucleus (r*), the critical free energy of nucleus (螖G*) and the molecular number of critical nucleus (i*) were evaluated in the controlled nucleation condition. The critical nucleation parameters varied with increased temperature, and the nucleation rate increased with increased supersaturation.