Gold Meets Rhodium: Tandem One-Pot Synthesis of 尾-Disubstituted Ketones via Meyer鈥揝chuster Rearrangement and Asymmetric 1,4-Addition

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• 作者：Max M. Hansmann ; A. Stephen K. Hashmi ; Mark Lautens
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 5, 2013
• 年：2013
• 卷：15
• 期：13
• 页码：3226-3229
• 全文大小：292K
• 年卷期：v.15,no.13(July 5, 2013)
• ISSN：1523-7052

文摘

An asymmetric one-pot tandem Au/Rh-catalyzed synthesis of highly enantioenriched 尾-disubstituted ketones starting from racemic propargyl alcohols is disclosed. The compatibility of the two metal complexes (Au/Rh) and their orthogonal ligand systems (NHC/diene) in this bimetallic catalytic system is investigated.