Azaphilones and p-Terphenyls from the Mangrove Endophytic Fungus Penicillium chermesinum (ZH4-E2) Isolated from the South China Sea

详细信息    查看全文

• 作者：Hongbo Huang ; Xiaojun Feng ; Ze鈥檈n Xiao ; Lan Liu ; Hanxiang Li ; Lin Ma ; Yongjun Lu ; Jianhua Ju ; Zhigang She ; Yongcheng Lin
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：997-1002
• 全文大小：836K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Eight secondary metabolites, including three new azaphilones (chermesinones A鈥揅, 1鈥?b>3), three new p-terphenyls (6鈥?O-desmethylterphenyllin, 4; 3-hydroxy-6鈥?O-desmethylterphenyllin, 5; 3鈥测€?deoxy-6鈥?O-desmethylcandidusin B, 7), and two known p-terphenyls (6, 8), were isolated from the culture of the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2). Their structures were established by spectroscopic analysis. The absolute configuration of 1 was determined by X-ray crystallography. Terphenyls 4, 5, and 6 exhibited strong inhibitory effects against 伪-glucosidase with IC₅₀ values of 0.9, 4.9, and 2.5 渭M, respectively. Terphenyls 7 and 8 showed inhibitory activity toward acetylcholinesterase with IC₅₀ values of 7.8 and 5.2 渭M.