Coordination Bonding-Based Mesoporous Silica for pH-Responsive Anticancer Drug Doxorubicin Delivery
详细信息 查看全文
- 作者：Haoquan Zheng ; Ying Wang ; Shunai Che
- 刊名：Journal of Physical Chemistry C
- 出版年：2011
- 出版时间：September 1, 2011
- 年：2011
- 卷：115
- 期：34
- 页码：16803-16813
- 全文大小：1165K
- 年卷期：v.115,no.34(September 1, 2011)
- ISSN：1932-7455
文摘
On the basis of amino group-functionalized mesoporous materials, a pH-responsive system by constructing a designable coordination bonding-based 鈥淣H2鈥搈etal鈥揇OX鈥?architecture in mesopores has been investigated. The DOX can be released by the cleavage of either the 鈥淣H2鈥搈etal鈥?or the 鈥渕etal鈥揇OX鈥?coordinate bonding in response to pH variations. Here, the strengths of coordination bondings on both sides have been designed and fabricated from the aspects of NH2 loading amount, metal ion, and the counteranion accompanying the metal ion. It has been found that (i) the increase of amino group loading led to increased release percentage of the DOX under physiological condition due to a small number of 鈥渕etal鈥揇OX鈥?bondings resulted from too many 鈥淣H2鈥搈etal鈥?bondings, and this tendency finally resulted in a decrease in its stability; (ii) the pH-sensitivity can be controlled by choosing the type of metal ion; and (iii) the physiological stabilities of 鈥淣H2鈥搈etal鈥揇OX鈥?architectures formed by various metal sources are in the decreasing order of CH3COO鈥?/sup> > NO32鈥?/sup> > SO42鈥?/sup> > Cl鈥?/sup>, indicating that different counteranions gave rise to different coordination bonding strengths of the architectures. Amino group loading amount of 2.4 mmol/g and CH3COO鈥?/sup> counterion were suitable for 鈥淣H2鈥揨n鈥揇OX鈥?pH-responsive delivery system, which was stable under physiological condition, while it was unstable with the DOX release triggered by the slight decrease to pH 6.0鈥?.0. The efficient cellular uptake of this pH-responsive system for cancer cells has been confirmed by cell assay. This coordination bonding-based pH-responsive system provides a new insight into the molecular factors governing the strength of chemical bonds in restrictive domain, which would open up new possibilities of porous materials for advanced applications in adsorption and desorption of biological and paramedical materials for antitumor therapy.