Toward More 鈥淚deal鈥?Polyketide Natural Product Synthesis: A Step-Economical Synthesis of Zincophorin Methyl Ester

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• 作者：Tyler J. Harrison ; Stephen Ho ; James L. Leighton
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：May 18, 2011
• 年：2011
• 卷：133
• 期：19
• 页码：7308-7311
• 全文大小：827K
• 年卷期：v.133,no.19(May 18, 2011)
• ISSN：1520-5126

文摘

A highly efficient and step-economical synthesis of zincophorin methyl ester has been achieved. The unprecedented step economy of this zincophorin synthesis is principally due to an application of the tandem silylformylation鈥揷rotylsilylation/Tamao oxidation鈥揹iastereoselective tautomerization reaction, which achieves in a single step what would typically require a significant multistep sequence.