Bioactive Compounds from Vitex leptobotrys

详细信息    查看全文

• 作者：Wenhui Pan ; Kanglun Liu ; Yifu Guan ; Ghee Teng Tan ; Nguyen Van Hung ; Nguyen Manh Cuong ; D. Doel Soejarto ; John M. Pezzuto ; Harry H. S. Fong ; Hongjie Zhang
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：March 28, 2014
• 年：2014
• 卷：77
• 期：3
• 页码：663-667
• 全文大小：302K
• 年卷期：v.77,no.3(March 28, 2014)
• ISSN：1520-6025

文摘

A new lignan, vitexkarinol (1), as well as a known lignan, neopaulownin (2), a known chalcone, 3-(4-hydroxyphenyl)-1-(2,4,6-trimethoxyphenyl)-2-propen-1-one (3), two known dehydroflavones, tsugafolin (4) and alpinetin (5), two known dipeptides, aurantiamide and aurantiamide acetate, a known sesquiterpene, vemopolyanthofuran, and five known carotenoid metabolites, vomifoliol, dihydrovomifoliol, dehydrovomifoliol, loliolide, and isololiolide, were isolated from the leaves and twigs of Vitex leptobotrys through bioassay-guided fractionation. The chalcone (3) was found to inhibit HIV-1 replication by 77% at 15.9 渭M, and the two dehydroflavones (4 and 5) showed weak anti-HIV activity with IC<sub>50sub> values of 118 and 130 渭M, respectively, while being devoid of cytotoxicity at 150 渭M. A chlorophyll-enriched fraction of V. leptobotrys, containing pheophorbide a, was found to inhibit the replication of HIV-1 by 80% at a concentration of 10 渭g/mL. Compounds 1 and 3 were further selected to be evaluated against 21 viral targets available at NIAID (National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA).