Synthesis of Biheterocycles Based on Quinolinone, Chromone, and Coumarin Scaffolds by Palladium-Catalyzed Decarboxylative Couplings
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- 作者：K. Harsha Vardhan Reddy ; Jean-Daniel Brion ; Samir Messaoudi ; Mouad Alami
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：January 15, 2016
- 年：2016
- 卷：81
- 期：2
- 页码：424-432
- 全文大小：511K
- ISSN：1520-6904
文摘
An efficient Pd-catalyzed decarboxylative coupling of heterocyclic carboxylic acids with heterocyclic halides to achieve the synthesis of biheterocycles of biological interest has been reported. In all cases, the cross-coupling reactions take place rapidly in DMSO in good yields and efficiently proceed in the presence of a PdBr2/DPEphos catalytic system, furnishing the novel biheterocycles based on quinolin-4-one, quinolin-2-one, chromone, and coumarin scaffolds.