Targeting Epidermal Growth Factor Receptor with Ferrocene-Based Kinase Inhibitors

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• 作者：Jahangir Amin ; Irina Chuckowree ; Graham J. Tizzard ; Simon J. Coles ; Minghua Wang ; John P. Bingham ; John A. Hartley ; John Spencer
• 刊名：Organometallics
• 出版年：2013
• 出版时间：January 28, 2013
• 年：2013
• 卷：32
• 期：2
• 页码：509-513
• 全文大小：332K
• 年卷期：v.32,no.2(January 28, 2013)
• ISSN：1520-6041

文摘

A series of ferrocene analogues based on a 6,7-dimethoxy-N-phenylquinazolin-4-amine template has been synthesized, and two compounds were characterized in the solid state by X-ray crystallography. The compounds have been tested for in vitro anticancer activity, against epidermal growth receptor (EGFR), and submicromolar IC₅₀ values have been determined.