文摘
In vivo antioxidative activity of propolis was evaluated on the basis of ameliorative effects on theoxidative stress induced by vitamin E deficiency in rats. The control group was fed vitamin E-deficientdiet, and the propolis group was fed vitamin E-deficient diet supplemented with 1% of propolis for4 and 8 weeks. Comparisons were made in tissue concentrations of vitamin C, vitamin E, and lipidhydroperoxides between these groups. No significant difference was observed in tissue vitamin Econcentration between these groups after both 4 and 8 weeks. After 4 weeks, the plasma vitaminC concentration of the propolis group was significantly higher than that of the control group. After8 weeks, the tissue concentrations of vitamin C in the kidney, stomach, small intestine, and largeintestine of the propolis group were significantly higher than those of the control group. These resultssuggest that some components of propolis are absorbed to circulate in the blood and behave as ahydrophilic antioxidant that saves vitamin C. The concentration of lipid hydroperoxides in the largeintestine of the propolis group was significantly lower than that of the control group after 8 weeks.These results suggest that propolis exerts its antioxidative effect where it is assumed to accumulate,such as on the kidney, where it is excreted, and on the gastrointestinal tract, where propolisinfluences these tissues even from the outside of the cell.Keywords: Antioxidant; lipid hydroperoxide; propolis; vitamin C; vitamin E