Polymeric Framboidal Nanoparticles Loaded with a Carbon Monoxide Donor via Phenylboronic Acid-Catechol Complexation

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• 作者：André J. van der Vlies ; Ryosuke Inubushi ; Hiroshi Uyama ; Urara Hasegawa
• 刊名：Bioconjugate Chemistry
• 出版年：2016
• 出版时间：June 15, 2016
• 年：2016
• 卷：27
• 期：6
• 页码：1500-1508
• 全文大小：602K
• 年卷期：0
• ISSN：1520-4812

文摘

Carbon monoxide (CO) is an essential gaseous signaling molecule in the human body. Toward the controlled delivery of CO to the target tissues or cells, nanomaterial-based CO donors have attracted growing attention. Here, we present CO-releasing polymeric nanoparticles (CONPs) prepared by simple mixing of phenylboronic acid-containing framboidal nanoparticles with the catechol-bearing CO-donor Ru(CO)₃Cl(L-DOPA) via phenylboronic acid-catechol complexation. The CONPs release CO in response to cysteine and suppress the production of the pro-inflammatory mediators interleukin 6 (IL-6) and nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine macrophages. This CONP platform may show promise in therapeutic applications of CO.