Cytotoxic Biscembranes from the Soft Coral Sarcophyton glaucum

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• 作者：Tetsuo Iwagawa ; Kanta Hashimoto ; Yukiko Yokogawa ; Hiroaki Okamura ; Munehiro Nakatani ; Matsumi Doe ; Yoshiki Morimoto ; Kaoru Takemura
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：May 22, 2009
• 年：2009
• 卷：72
• 期：5
• 页码：946-949
• 全文大小：125K
• 年卷期：v.72,no.5(May 22, 2009)
• ISSN：1520-6025

文摘

Seven new tetracyclic biscembranes (1−7) have been isolated from the soft coral Sarcophyton glaucum. Four (1−4) may be formed biogenetically by a Diels−Alder reaction of Δ⁴⁽⁵⁾ and Δ⁸⁽⁹⁾ geometrical isomers of methyl sarcoate and Δ^{21(34), 35(36)} dienes, including two with a tetrahydrofuran ring between C-27 and C-30 (3, 4), and three biscembranes (5−7) are probably derived from methyl sarcoate isomers with Δ^{1(14), 4(5), 8(9)} and a cembrane diene. Their structures were established on the basis of spectroscopic methods. Six of them (1−5, 7) exhibited weak cytotoxic activity against proliferation of human promyelocytic leukemia cells (HL-60).