A Chiral Electrophilic Selenium Catalyst for Highly Enantioselective Oxidative Cyclization

详细信息    查看全文

• 作者：Yu Kawamata ; Takuya Hashimoto ; Keiji Maruoka
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：April 27, 2016
• 年：2016
• 卷：138
• 期：16
• 页码：5206-5209
• 全文大小：397K
• 年卷期：0
• ISSN：1520-5126

文摘

Chiral electrophilic selenium catalysts have been applied to catalytic asymmetric transformations of alkenes over the past two decades. However, highly enantioselective reactions with a broad substrate scope have not yet been developed. We report the first successful example of this reaction employing a catalyst based on a rigid indanol scaffold, which can be easily synthesized from a commercially available indanone. The reaction efficiently converts β,γ-unsaturated carboxylic acids into various enantioenriched γ-butenolides under mild conditions.