Frustrated Lewis Acid/Brønsted Base Catalysts for Direct Enantioselective α-Amination of Carbonyl Compounds
详细信息 查看全文
- 作者：Ming Shang ; Xiaoxu Wang ; Seung Moh Koo ; Jennifer Youn ; Jessica Z. Chan ; Wenzhi Yao ; Brian T. Hastings ; Masayuki Wasa
- 刊名：Journal of the American Chemical Society
- 出版年：2017
- 出版时间：January 11, 2017
- 年：2017
- 卷：139
- 期：1
- 页码：95-98
- 全文大小：466K
- ISSN：1520-5126
文摘
A method for enantioselective direct α-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Brønsted base complex is disclosed. Cooperative functioning of the Lewis acid and Brønsted base components gives rise to in situ enolate generation from monocarbonyl compounds. Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers α-aminocarbonyl compounds in high enantiomeric purity.