Relative and Absolute Stereochemistry of Quinadoline B, an Inhibitor of Lipid Droplet Synthesis in Macrophages
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- 作者：Nobuhiro Koyama ; Yusuke Inoue ; Masae Sekine ; Yoichi Hayakawa ; Hiroshi Homma ; Satoshi O̅ ; mura ; Hiroshi Tomoda
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：November 20, 2008
- 年：2008
- 卷：10
- 期：22
- 页码：5273-5276
- 全文大小：155K
- 年卷期：v.10,no.22(November 20, 2008)
- ISSN：1523-7052
文摘
New fungal metabolites, designated quinadolines A (1) and B (2), were isolated from culture broth of Aspergillus sp. FKI-1746, and their structures were elucidated by NMR spectroscopy. The complete relative and absolute stereochemistry of 2 was determined by X-ray crystallography and amino acid analysis using a chiral column. Quinadolines moderately inhibited lipid droplet synthesis in mouse macrophages.