Second-Generation Total Synthesis of Haterumalide NA Using B-Alkyl Suzuki–Miyaura Coupling
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- 作者：Ichiro Hayakawa ; Mitsuru Ueda ; Masashi Yamaura ; Yoichi Ikeda ; Yuta Suzuki ; Kensaku Yoshizato ; Hideo Kigoshi
- 刊名：Organic Letters
- 出版年：2008
- 出版时间：May 1, 2008
- 年：2008
- 卷：10
- 期：9
- 页码：1859 - 1862
- 全文大小：148K
- 年卷期：v.10,no.9(May 1, 2008)
- ISSN：1523-7052
文摘
Second-generation total synthesis of haterumalide NA, a potent cytotoxic marine macrolide, was achieved by using B-alkyl Suzuki–Miyaura coupling and Nozaki–Hiyama–Kishi coupling as key steps (1.2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate.