Biologically Active Aspidofractinine Alkaloids from Kopsia singapurensis

详细信息    查看全文

• 作者：G. Subramaniam ; Osamu Hiraku ; Masahiko Hayashi ; Takashi Koyano ; Kanki Komiyama ; Toh-Seok Kam
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：71
• 期：1
• 页码：53 - 57
• 全文大小：89K
• 年卷期：v.71,no.1(January 2008)
• ISSN：1520-6025

文摘

Ten new indole alkaloids of the aspidofractinine type, in addition to several recently reported indole alkaloids and 20 other known alkaloids, were obtained from the leaf and stem-bark extract of the Malayan Kopsia singapurensis, viz., kopsimalines A−E (1−5), kopsinicine (6), kopsofinone (7), and kopsiloscines H−J (8−10). The structures of these alkaloids were determined using NMR and MS analysis. Kopsimalines A (1), B (2), C (3), D (4), and E (5) and kopsiloscine J (10) were found to reverse multidrug-resistance in vincristine-resistant KB cells, with 1 showing the highest potency.