Stereoselective Synthesis of MLN4924, an Inhibitor of NEDD8-Activating Enzyme
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- 作者：Hyuk Woo Lee ; Soo Kyung Nam ; Won Jun Choi ; Hea Ok Kim ; Lak Shin Jeong
- 刊名：Journal of Organic Chemistry
- 出版年：2011
- 出版时间：May 6, 2011
- 年：2011
- 卷：76
- 期：9
- 页码：3557-3561
- 全文大小：783K
- 年卷期：v.76,no.9(May 6, 2011)
- ISSN：1520-6904
文摘
MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route involving stereoselective reduction, regioselective cleavage of an isopropylidene moiety, and selective displacement of a cyclic sulfate moiety as key steps.