Palladium-Catalyzed Enantioselective Diboration of Prochiral Allenes
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- 作者：Nicholas F. Pelz ; Angela R. Woodward ; Heather E. Burks ; Joshua D. Sieber ; and James P. Morken
- 刊名：Journal of the American Chemical Society
- 出版年：2004
- 出版时间：December 22, 2004
- 年：2004
- 卷：126
- 期：50
- 页码：16328 - 16329
- 全文大小：41K
- 年卷期：v.126,no.50(December 22, 2004)
- ISSN：1520-5126
文摘
Pd-catalyzed diboration of prochiral allenes occurs exclusively at the internal position and is remarkably accelerated in the presence of Lewis basic ligand structures. On the basis of preliminary observations, a chiral ligand was employed, and the enantiomeric excess of a variety of diboration products was found to be in the range of 86-92% ee. The chiral diboron reaction products should be useful in organic synthesis, and preliminary experiments suggest that they may participate in allylation reactions with a high level of chirality transfer.