PICKScreens, A New Database for the Comparison of Crystallization Screens for Biological Macromolecules

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• 作者：Tanja Hedderich ; Marco Marcia ; Ju虉rgen Ko虉pke ; Hartmut Michel
• 刊名：Crystal Growth & Design
• 出版年：2011
• 出版时间：February 2, 2011
• 年：2011
• 卷：11
• 期：2
• 页码：488-491
• 全文大小：808K
• 年卷期：v.11,no.2(February 2, 2011)
• ISSN：1528-7505

文摘

Extensive screening during crystallization trials is necessary, especially for challenging but interesting targets, that is, large multisubunit complexes or membrane proteins. Producing high amounts of such macromolecules is difficult, so it is important to perform screening efficiently. However, commercial screens are redundant, leading to unnecessary or unwanted sample consumption, and cannot be visually compared, because the manufacturers鈥?formulations are not formatted uniformly. PICKScreens, a database reporting Profile of Identities among Crystallization Kit Screens, will help crystallographers 鈥減ick鈥?screens in a more rational manner, minimizing sample consumption and hopefully enhancing their success rate. It is available at gistration.cc.biophys.mpg.de/fam-core/" class="extLink">https://registration.cc.biophys.mpg.de/fam-core/.