Scalable Enantioseparation of Amino Acid Derivatives Using Continuous Liquid−Liquid Extraction in a Cascade of Centrifugal Contactor Separators

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• 作者：Boelo Schuur ; Andrew J. Hallett ; Jozef G. M. Winkelman ; Johannes G. de Vries ; Hero J. Heeres
• 刊名：Organic Process Research & Development
• 出版年：2009
• 出版时间：September 18, 2009
• 年：2009
• 卷：13
• 期：5
• 页码：911-914
• 全文大小：153K
• 年卷期：v.13,no.5(September 18, 2009)
• ISSN：1520-586X

文摘

Using a cascade of six centrifugal contactor separators in a countercurrent liquid−liquid extraction mode allowed the separation of one of the enantiomers of 3,5-dinitrobenzoyl-leucine in 55% yield and 98% ee using a catalytic amount of a chiral host compound based on a cinchona alkaloid. This method allows the preparation of kilograms of enantiopure material in table-top-sized equipment that can be operated in a fume cupboard. The methodology can be easily scaled up to ton amounts as large-volume centrifugal contactor separators are commercially available as well.