Optimization Studies on the Hydro-acylation of 1-Alkenes to 伪-Methylketones using a Homogeneous Palladium/Josiphos Catalyst
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- 作者：Hans Heeres ; Adri J. Minnaard ; Bart Hessen ; Hero J. Heeres
- 刊名：Organic Process Research & Development
- 出版年：2012
- 出版时间：March 16, 2012
- 年：2012
- 卷：16
- 期：3
- 页码：400-408
- 全文大小：540K
- 年卷期：v.16,no.3(March 16, 2012)
- ISSN：1520-586X
文摘
The effect of process conditions (temperature, partial pressures of CO and H2) on the product selectivity and ee of the palladium-catalysed asymmetric hydro-acylation of 1-pentene in dichloromethane with the chiral Josiphos ligand (SL-J008-1, L1) was investigated. The highest ee value (73%) for the desired product 4-methyl-5-decanone (1) was obtained at the lowest temperature in the range (30 掳C). The selectivity for 1 was between 12 and 20 mol % at 30 掳C, though considerably higher at 90 掳C (59 mol %). Statistical modeling was applied to quantify the influence of the process conditions on the product selectivity and ee.