Bridged Epipolythiodiketopiperazines from Penicillium raciborskii, an Endophytic Fungus of Rhododendron tomentosum Harmaja
详细信息 查看全文
- 作者：Marena Kajula ; Joshua M. Ward ; Ari Turpeinen ; Mysore V. Tejesvi ; Juho Hokkanen ; Ari Tolonen ; Heikki Häkkänen ; Pere Picart ; Janne Ihalainen ; Hans-Georg Sahl ; Anna Maria Pirttilä ; Sampo Mattila
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：April 22, 2016
- 年：2016
- 卷：79
- 期：4
- 页码：685-690
- 全文大小：292K
- 年卷期：0
- ISSN：1520-6025
文摘
Three new epithiodiketopiperazine natural products [outovirin A (1), outovirin B (2), and outovirin C (3)] resembling the antifungal natural product gliovirin have been identified in extracts of Penicillium raciborskii, an endophytic fungus isolated from Rhododendron tomentosum. The compounds are unusual for their class in that they possess sulfide bridges between α- and β-carbons rather than the typical α–α bridging. To our knowledge, outovirin A represents the first reported naturally produced epimonothiodiketopiperazine, and antifungal outovirin C is the first reported trisulfide gliovirin-like compound. This report describes the identification and structural elucidation of the compounds by LC-MS/MS and NMR.