Synthesis of Tetracyclic Quinazolinones Using a Visible-Light-Promoted Radical Cascade Approach

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• 作者：Yue-Yue Han ; Heng Jiang ; Ruzhi Wang ; Shouyun Yu
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：August 19, 2016
• 年：2016
• 卷：81
• 期：16
• 页码：7276-7281
• 全文大小：392K
• 年卷期：0
• ISSN：1520-6904

文摘

A practical approach for the synthesis of tetracyclic pyrroloquinazolines using photoredox strategy has been developed. The visible-light-promoted intramolecular single-electron-transfer process between photocatalyst and N-(2-iodobenzyl)-N-acylcyanamides is considered to be involved in this transformation. Targeted pyrroloquinazoline derivatives (15 examples) are presented in good isolated yields (30%–88%).