Efficient Synthesis of Chiral 2,2鈥?Bipyrrolidines by an anti-Selective Alkene Diamination

详细信息    查看全文

• 作者：Christian H. M眉ller ; Roland Fr枚hlich ; Constantin G. Daniliuc ; Ulrich Hennecke
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：December 7, 2012
• 年：2012
• 卷：14
• 期：23
• 页码：5944-5947
• 全文大小：268K
• 年卷期：v.14,no.23(December 7, 2012)
• ISSN：1523-7052

文摘

The rapid and efficient construction of complex chiral bicyclic amines is possible using a novel alkene diamination reaction. Electrophilic iodinating agents promote the intramolecular anti-selective diamination of alkenes and allow the efficient synthesis of chiral amines such as trans-bipyrrolidines.