Development of a Continuous Flow Scale-Up Approach of Reflux Inhibitor AZD6906

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• 作者：Tomas Gustafsson ; Henrik S枚rensen ; Fritiof Pont茅n
• 刊名：Organic Process Research & Development
• 出版年：2012
• 出版时间：May 18, 2012
• 年：2012
• 卷：16
• 期：5
• 页码：925-929
• 全文大小：269K
• 年卷期：v.16,no.5(May 18, 2012)
• ISSN：1520-586X

文摘

Early scale-up work of a promising reflux inhibitor AZD6906 is described. Two steps of an earlier route were adapted to be performed in continuous flow to avoid issues related to batch procedures, resulting in a robust method with reduced cost of goods and improved product quality. Toxic and reactive reagents and starting materials could be handled in a flow regime, thereby allowing safer and more convenient reaction optimization and production.