Total Synthesis of (±)-Gracilioether F

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• 作者：Xin-Yue Shen ; Xiao-Shui Peng ; Henry N. C. Wong
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 4, 2016
• 年：2016
• 卷：18
• 期：5
• 页码：1032-1035
• 全文大小：320K
• ISSN：1523-7052

文摘

Total synthesis of (±)-gracilioether F was achieved via a pivotal reductive cleavage of 1,2-dioxane from allenic ester in 11 steps. The key 1,2-dioxane species, derived from singlet oxygen and a diene, could be used as a common precursor for a stereocontrolled formation of the crucial 1,4-diol through a reductive cleavage.