High Intensity Focused Ultrasound Responsive Metallo-supramolecular Block Copolymer Micelles

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• 作者：Bo Liang ; Rui Tong ; Zhenhua Wang ; Shengwei Guo ; Hesheng Xia
• 刊名：Langmuir
• 出版年：2014
• 出版时间：August 12, 2014
• 年：2014
• 卷：30
• 期：31
• 页码：9524-9532
• 全文大小：522K
• ISSN：1520-5827

文摘

The metal鈥搒upramolecular diblock copolymer containing mechano-labile bis(terpyridine)鈥揅u(II) complex linkage in the junction point was synthesized. These metal鈥搇igand containing amphiphilic copolymers are able to self-assemble in aqueous solution to form spherical micelles with poly(propylene glycol) block forming the hydrophobic core. It is found that high intensity focused ultrasound can open the copolymer micelles and trigger the release of the payload in the micelle. The micellar properties and release kinetics of encapsulated guest molecule in response to ultrasound stimuli were investigated. The weak Cu(II)鈥搕erpyridine dynamic bond in the copolymer chain can be cleaved under ultrasound and thus leads to the disruption of the copolymer micelle and the release of loaded cargo. This study will open up a new way for the molecular design of ultrasound modulated drug delivery systems.