Utilization of Photoinduced Charge-Separated State of Donor鈥揂cceptor-Linked Molecules for Regulation of Cell Membrane Potential and Ion Transport
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- 作者：Tomohiro Numata ; Tatsuya Murakami ; Fumiaki Kawashima ; Nobuhiro Morone ; John E. Heuser ; Yuta Takano ; Kei Ohkubo ; Shunichi Fukuzumi ; Yasuo Mori ; Hiroshi Imahori
- 刊名：The Journal of the American Chemical Society
- 出版年：2012
- 出版时间：April 11, 2012
- 年：2012
- 卷：134
- 期：14
- 页码：6092-6095
- 全文大小：270K
- 年卷期：v.134,no.14(April 11, 2012)
- ISSN：1520-5126
文摘
The control of ion transport across cell membranes by light is an attractive strategy that allows targeted, fast control of precisely defined events in the biological membrane. Here we report a novel general strategy for the control of membrane potential and ion transport by using charge-separation molecules and light. Delivery of charge-separation molecules to the plasma membrane of PC12 cells by a membranous nanocarrier and subsequent light irradiation led to depolarization of the membrane potential as well as inhibition of the potassium ion flow across the membrane. Photoregulation of the cell membrane potential and ion transport by using charge-separation molecules is highly promising for control of cell functions.