Diversonol and Blennolide Derivatives from the Endophytic Fungus Microdiplodia sp.: Absolute Configuration of Diversonol

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• 作者：Imran Nafees Siddiqui ; Aqib Zahoor ; Hidayat Hussain ; Ishtiaq Ahmed ; Viqar Uddin Ahmad ; Daniele Padula ; Siegfried Draeger ; Barbara Schulz ; Kathrin Meier ; Michael Steinert ; Tibor Kurta虂n ; Ulrich Flo虉rke ; Gennaro Pescitelli ; Karsten Krohn
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：March 25, 2011
• 年：2011
• 卷：74
• 期：3
• 页码：365-373
• 全文大小：988K
• 年卷期：v.74,no.3(March 25, 2011)
• ISSN：1520-6025

文摘

Chemical investigation of the fungal strain Microdiplodia sp. isolated from the shrub Lycium intricatum led to the isolation of four new compounds: a hexahydroxanthone (2), a 2,3-dihydrochroman-4-one (3), a 7-oxoxanthone derivative (4), and a 1,4-oxazepan-7-one (5). The relative configurations of the new compounds were determined by intensive NMR investigations, notably NOESY experiments at different temperatures. The absolute configurations of the well-known fungal metabolite diversonol (1) and of other xanthone derivatives (3, 4) were established by means of TDDFT ECD calculations. Most of the metabolites were biologically active, with antibacterial activity against Legionella pneumophila and/or antifungal activity against Microbotryum violaceum.