BODIPY-Based Molecular Probe for Imaging of Cerebral 尾-Amyloid Plaques
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- 作者：Masahiro Ono ; Hiroyuki Watanabe ; Hiroyuki Kimura ; Hideo Saji
- 刊名：ACS Chemical Neuroscience
- 出版年：2012
- 出版时间：April 18, 2012
- 年：2012
- 卷：3
- 期：4
- 页码：319-324
- 全文大小：272K
- 年卷期：v.3,no.4(April 18, 2012)
- ISSN：1948-7193
文摘
We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of 尾-amyloid plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for synthetic A尾 aggregates. 尾-Amyloid plaques in Tg2576 mouse brain were clearly visualized with BAP-1. In addition, the labeling of 尾-amyloid plaques was demonstrated in vivo in Tg2576 mice. These results suggest BAP-1 to be a useful fluorescent probe for the optical imaging of cerebral 尾-amyloid plaques in patients with Alzheimer鈥檚 disease.