Multiported Pulsed Valve Interface for a Linear Quadrupole Ion Trap Mass Spectrometer to Enable Rapid Screening of Multiple Functional-Group Selective Ion鈥揗olecule Reactions

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• 作者：Tiffany Jarrell ; James Riedeman ; Mark Carlsen ; Randall Replogle ; Tim Selby ; Hilkka Kentt盲maa
• 刊名：Analytical Chemistry
• 出版年：2014
• 出版时间：July 1, 2014
• 年：2014
• 卷：86
• 期：13
• 页码：6533-6539
• 全文大小：389K
• ISSN：1520-6882

文摘

Ion鈥搈olecule reactions provide a powerful tool for structural elucidation of ionized pharmaceutical analytes in tandem mass spectrometry. However, all previous interfaces for the introduction of reagents for ion鈥搈olecule reactions have utilized a single reagent approach. In this study, a multiported pulsed valve system was designed and characterized for rapid introduction of three neutral reagents into a linear quadrupole ion trap. Additionally, automatic triggering was used to allow for the introduction of the reagents on a chromatographic time scale. This system enables automatic, high throughput screening of complex mixtures by using at least three different ion鈥搈olecule reactions. Further, rapid testing of new neutral reagents is also possible.