Abyssomicin I, a Modified Polycyclic Polyketide from Streptomyces sp. CHI39

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• 作者：Yasuhiro Igarashi ; Linkai Yu ; Satoshi Miyanaga ; Takao Fukuda ; Noriko Saitoh ; Hiroaki Sakurai ; Ikuo Saiki ; Pablo Alonso-Vega ; Martha E. Trujillo
• 刊名：Journal of Natural Products
• 出版年：2010
• 出版时间：November 29, 2010
• 年：2010
• 卷：73
• 期：11
• 页码：1943-1946
• 全文大小：171K
• 年卷期：v.73,no.11(November 29, 2010)
• ISSN：1520-6025

文摘

Abyssomicin I (1), a new modified polycyclic polyketide, was isolated from the culture extract of a soil-derived Streptomyces sp. The structure of 1 was elucidated by interpretation of NMR and other spectroscopic data. The stereochemistry of the new compound was assigned by NOE analysis, chemical derivatization, and application of the modified Mosher method. While 1 was inactive against bacteria and yeasts, the oxidized derivative 7 showed weak activities against Gram-positive bacteria. Compounds 1 and 7 exhibited inhibitory effects on tumor cell invasion with IC₅₀ values of 11 and 0.21 μM, respectively.