Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers

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• 作者：Teigo Asai ; Yu-Ming Chung ; Hiroaki Sakurai ; Tomoji Ozeki ; Fang-Rong Chang ; Kouwa Yamashita ; Yoshiteru Oshima
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：January 20, 2012
• 年：2012
• 卷：14
• 期：2
• 页码：513-515
• 全文大小：205K
• 年卷期：v.14,no.2(January 20, 2012)
• ISSN：1523-7052

文摘

The concomitant addition of the histone deacetylase inhibitor and the DNA methyltransferase inhibitor to the culture medium of an entomopathogenic fungus, Isaria tenuipes, greatly enhanced its secondary metabolite production and led to the isolation of tenuipyrone (1), a novel polyketide with an unprecedented tetracyclic ring system bearing a spiroketal structural component, along with two known C₁₀-polyketides, cephalosporolide B (2), which is a plausible biosynthetic precursor of 1, and cephalosporolide F (3).