Development of Antimicrobial Thermoplastic Material from Archaeal Poly-纬-l-Glutamate and Its Nanofabrication
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- 作者：Makoto Ashiuchi ; Kenzo Fukushima ; Haruna Oya ; Toshihumi Hiraoki ; Shigeo Shibatani ; Nogiho Oka ; Hirokazu Nishimura ; Hirofumi Hakuba ; Masahiko Nakamori ; Masaru Kitagawa
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2013
- 出版时间：March 13, 2013
- 年：2013
- 卷：5
- 期：5
- 页码：1619-1624
- 全文大小：371K
- 年卷期：v.5,no.5(March 13, 2013)
- ISSN：1944-8252
文摘
Here we describe a stoichiometric ion-complex of archaeal poly-纬-l-glutamate (l-PGA) and hexadecylpyridinium cation (HDP+), called PGAIC, which shows remarkable chemical resistance and potential as a novel functional thermoplastic. PGAIC films suppressed the proliferation of prokaryotic (Escherichia coli, Bacillus subtilis, Salmonella typhimurium, and Staphylococcus aureus) and eukaryotic (Saccharomyces cerevisiae) microorganisms. Moreover, its antifungal activity was demonstrated against a prevalent species of Candida (Candida albicans) and a filamentous fungus (Aspergillus niger). The minimal inhibitory concentrations were estimated as 0.25 mg mL鈥?, and zones of growth inhibition appeared when PGAIC-coated polyethylene terephthalate (PET) films were placed in culture plates, whereas PET had very little effect on fungal growth. Soluble PGAIC thus shows promises as an antimicrobial and as a coating substrate. We also succeeded in synthesizing an l-PGA-based nanofiber using an ethanol solution of PGAIC.