Novel Strategy for Synthesis of Substituted Benzimidazo[1,2-a]quinolines

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• 作者：Jun-ya Kato ; Yutaro Ito ; Ryosuke Ijuin ; Hiroshi Aoyama ; Tsutomu Yokomatsu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：July 19, 2013
• 年：2013
• 卷：15
• 期：14
• 页码：3794-3797
• 全文大小：225K
• 年卷期：v.15,no.14(July 19, 2013)
• ISSN：1523-7052

文摘

An efficient method for the synthesis of benzimidazo[1,2-a]quinolines under transition-metal-free conditions has been developed through a cascade reaction involving sequential aromatic nucleophilic substitution and intramolecular Knoevenagel condensation reactions. This method is applicable for the synthesis of a wide range of benzimidazo[1,2-a]quinoline derivatives from readily available 2-fluoroarylaldehyde and benzimidazole substrates.